In-Line Vis-NIR Spectral Analysis for the Column Chromatographic Processes of the Ginkgo biloba L. Leaves. Part II: Batch-to-Batch Consistency Evaluation of the Elution Process

An in-line monitoring method for the elution process of Ginkgo biloba L. leaves using visible and near-infrared spectroscopy in conjunction with multivariate statistical control (MSPC) was established. Experiments, including normal operating batches abnormal ones, were designed carried out. The MSPC model developed validated. abnormalities detected successfully by charts principal component scores, Hotelling T2, or DModX (distance to model). results suggested that established can be used batch-to-batch consistency evaluation process.